I have to hand it to you Eric, you are never short of industry, the willingness to do the legwork, but it looks to me like sometimes science does not define itself broadly enough to take in the really valuable concepts that come out of things like Systems Engineering. This is science applied to the task you describe as the theory of everything, but it's something that was developed in industry rather than in academic science, and it looks like academic science often doesn't like to see things developed in industry as having much merit.
Anyhow we might say that the theory of everything is the Grand system of Everything, and there are concepts in systems Engineering where we really can routinely wind in all knowledge, even knowledge about human nature, and machine intelligence.
It actually doesn't matter much how detailed this view is, because resolution can always be added by looking closer at any specific part of the system. What matters is that we get the overall structure correct, such that it does genuinely accommodate everything, and that we can use any part of it to guide or design our physical activities so that we fit with what we can see are the Grand purposes of creative nature (Life).
I suspect the answers you seek are in the Systems Engineering, rather than in the science.